Immune
activation of the central or peripheral nervous system (CNS or PNS) has been
shown to play a key role in the pathogenesis of many neurological disorders.
Basic concepts in Clinical Neuroimmunology have changed significantly during
the last 10 years, and are constantly evolving. New data has driven treatment
concepts for a large number of autoimmune diseases, none more so than multiple
sclerosis. As this area of research has become increasingly active and
productive, the need for a comprehensive up-to-date handbook has become
apparent.
Clinical Neuroimmunology:
Multiple Sclerosis and Related Disorders has been written
with the clinician in mind and targets residents, fellows, internists, nurse
practitioners, as well as general neurologists. The aim of this book is to make
recent developments in neuroimmunology accessible to the clinician who feels
daunted by such advances, and requires a clear explanation of the scientific
and clinical issues. The chapters have been written by experts in their fields.
The introduction, Part I is
written by Patricia K. Coyle and Lloyd Kasper and provide a logical and
straightforward overview of neuroimmunology. Part II consists
of eight chapters focused on multiple sclerosis. It includes a chapter on
Chronic Cerebrospinal Venous Insufficiency (CCSVI), a topic currently getting a
great deal of attention in the media. CCSVI is under investigation for its possible
association with MS. Another chapter written by Howard Weiner envisions MS 20
years in the future. Part III has
seven chapters and focuses on other CNS inflammatory disorders including
neuromyelitis optica, ADEM, CNS infections, and immunological aspects of cancer.
Part IV includes two chapters that
describe autoimmune disorders of the PNS. The final (V) part includes a single chapter that focuses on various
systemic diseases with prominent autoimmune CNS and PNS manifestations such as
Behcet’s disease, Sarcoidosis, and Systemic Lupus Erythematosis.
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