Monday 1 April 2013

Advanced organic chemistry: Part B: Reaction and Synthesis


Part B emphasizes the most important reactions used in organic synthesis. The material is organized by reaction type. Chapters 1 and 2 discuss the alkylation, conjugate addition and carbonyl addition/condensation reactions of enolates and other carbon  nucleophiles. Chapter 3 covers the use of nucleophilic substitution, both at saturated carbon and at carbonyl groups, in functional group of interconversions. Chapter 4 discusses electrophilic additions to alkenes and alkynes, including hydroboration. Chapter 5 discusses reduction reactions, emphasizing alkene and carbonyl group reductions. Concerted reactions, especially Diels-Alder and other cycloadditions and sigma tropic rearrangements, are considered in Chapter 6. Chapters 7, 8, and 9 cover organometallic reagents and intermediate in synthesis. The main-group elements lithium and magnesium as well as zinc are covered in Chapter 7. Chapter 8 deals with the transition metals, especially copper, palladium, and nickel. Chapter 9 discusses synthetic reactions involving boranes, silanes, and stannanes. Synthetic reactions which involve highly reactive intermediates carbocations, carbenes, and radicals are discussed in Chapter 10. Aromatic substitution by both electrophilic and nucleophilic reagents is the topic of Chapter 11. Chapter 12 discusses the most important synthetic procedures for oxidizing organic compounds. In each of these chapters, the most widely used reactions are illustrated by a number of specific examples of typical procedures. Chapter 13 introduces the concept of synthetic planning, including the use of protective groups and synthetic equivalents. Multistep syntheses are illustrated with several syntheses of juvabione, longifolene, Prelog Djerassi lactone, Taxol, epothilone. The chapter concludes with a discussion of solid-phase synthesis and its application in the synthesis of polypeptides and oligonucleotides, as well as to combinatorial synthesis. The control of reactivity to achieve specific syntheses is one of the overarching goals of organic chemistry. In the decade since the publication of the third edition, major advances have been made in the development of efficient new methods, particularly catalytic processes, and in means for control of reaction stereochemistry. For example, the scope and efficiency of palladium- catalyzed cross coupling have been greatly improved by optimization of catalysts by ligand modification. Among the developments in stereo control are catalysts for enantio selective reduction of ketones, improved methods for control of the stereoselectivity of Diels Alder reactions, and improved catalysts for enantioselective hydroxylation and epoxidation of alkenes. This volume assumes a level of familiarity with structural and mechanistic concepts comparable to that in the companion volume, Part A, Structure and Mechanisms. Together, the two volumes are intended to provide the advanced undergraduate or beginning graduate student in chemistry a sufficient foundation to comprehend and use the research literature in organic chemistry.




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