Janeway’s Immunobiology Posted by R Santhosh Kalash on 10/20/2013 11:18:00 am No comments

Janeway's Immunobiology is intended for undergraduate and graduate courses in immunology, as well as for medical students. The book can be used as an introduction to immunology but its scope is sufficiently comprehensive and deep to be useful for more advanced students and working immunologists. Immunobiology presents immunology from the consistent viewpoint of the host's interaction with an environment full of microbes and pathogens, and illustrates that the loss of any component of this system increases host susceptibility to some particular infection. The companion book, Case Studies in Immunology, provides an additional, integrated discussion of clinical topics (diseases covered in Case Studies are indicated by a symbol in the margin of Immunobiology).

This eighth edition retains the overall organization of the previous edition, and chapters in which the field has made important and rapid developments have been extensively revised. The discussion of innate immunity has been substantially expanded and its mechanisms are now treated in two separate chapters, presented in the order in which a pathogen would encounter innate defenses as it attempts to establish an infection. The immediate and soluble defenses are treated in Chapter 2. The complement system is introduced in the context of innate immunity, with the lectin pathway presented before the classical pathway of activation. The induced defenses of innate immunity-including a completely updated treatment of innate sensing-follows in Chapter 3, where various innate cell subsets and their receptors are also described. Signaling pathways are now presented as they are encountered, and not confined to a single chapter. Signaling pathways of the Toll-like receptors and other innate sensors are described in Chapter 3, while antigen receptor signaling pathways and cytokine and apoptotic pathways are retained in Chapter 7. Chapter 10 has been revised to place more emphasis on the trafficking of B cells in peripheral lymphoid organs and the locations at which they encounter antigen. Mucosal immunology (Chapter 12) has been expanded to include more discussion of responses to the commensal microbiota and the role of specialized dendritic cells and regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. The last four chapters-the clinical chapters Chapters 13-16)-reinforce the basic concepts discussed earlier with our latest understanding of the causes of disease, whether by inherited or acquired immunodeficiencies or by failures of immunological mechanisms. Chapter 16 describes how the immune response can be manipulated in attempts to combat infectious diseases, transplant rejection, and cancer. This chapter includes a complete update of the immunotherapeutics and vaccine sections. Aspects of evolution, which were confined to the last chapter of previous editions, are now discussed throughout the book as the relevant topics are encountered.

CLICK HERE TO DOWNLOAD

Read More »

Immunocytochemistry of Plant Cells Posted by R Santhosh Kalash on 10/20/2013 11:13:00 am No comments

Immunocytochemistry of plant cells has come a long way from the first review on this subject by Bruce Knox in the early 1980s. In that early review, our only tools were fluorescein-labeled antibodies for light microscopy and ferritin-labeled antibodies for electron microscopic observation. Frankly, in many of these early localizations the resolution of the tissue or the specificity of the labeling left much to be desired.

Immunocytochemistry of Plant Cells is the first book exclusively dedicated to this topic. The first and largest portion of the book is concerned with a group of proven protocols and variations on these protocols that might prove useful, many developed or modified in the author's laboratory. The second portion of the book covers the studies that have been published previously on each of the plant organelles. Numerous state of the art micrographs from researchers around the world are included to demonstrate typical results.

This book is organized essentially into two sections. The first chapter gives what we consider general protocols that work well on a variety of tissues and organelles, but also a number of variations that one might try in order to obtain a successful localization. Most of these were developed when the more standard protocols failed. The second portion of the book reviews by organelle of those techniques that may work better with that particular organelle, what unique immunocytochemical techniques can be used, and a review of some of the more important studies on that organelle. Some of the chapters also address the questions that are still outstanding and which could benefit from immunocytochemical studies.

CLICK HERE TO DOWNLOAD

Read More »

Roitt's Essential Immunology, Tenth Edition Posted by R Santhosh Kalash on 8/22/2013 06:14:00 pm No comments

It is now 30 years since the 1st Edition of Essential Immunology appeared, and it seemed that the time was now appropriate for the task of producing the 10th Edition to be shared. The new co-author, Peter Delves, has been a close colleague of Professor Roitt for many years and is a highly experienced teacher. A wide range of subjects have been extensively revised, restructured or updated, and advanced material is included in the figure legends to avoid disruption of the basic text. These subjects include:

• dendritic cells
• intraepithelial lymphocytes
• NK-T and y6 T-cells
• NK receptors
• receptor editing relating to receptor diversity
• non-classical MHC and the presentation of nonpeptidic
• antigens
• the role of chaperone proteins in antigen processing
• T-cell recognition of peptide-MHC reflecting the
• latest crystallographic studies
• arrays for analysis of gene expression
• tetramer evaluation of antigen-specific T-cells
• experimental genetic manipulation using conditional
• 'knockouts' employing the Lox/Cre
• system and 'knockins' to replace endogenous
• genes
• B- and T-cell signaling pathways and the role of
• adaptor proteins
• cytokine physiology
• chemokines and their receptors
• memory cells
• intimate links of innate and adaptive immunity
• the role of complement in modulating the adaptive immune response
• regulatory T-cells activation-induced cell death
• neuroendocrine influences on the immune system
• critical role of Pax 5 in B-cell differentiation
• molecular basis of thymic development
• signaling through pattern recognition systems
• prions
• viral hijacking of host processes as evasion
• mechanisms
• DNA vaccines
• mucosal adjuvants
• 'shot gun' approach to identification of vaccine
• candidates
• primary immunodeficiency including IL-7 receptor
• mutation, and deficiency of VDJ recombination in
• severe combined immunodeficiency 
• CCR5 CO-receptor for HIV infection of cells
• the importance of highly active anti-retroviral drug therapy and of healthy CD8 response dependent on robust CD4 Thl effectors in control of HIV infection
• pivotal role of IgE antibodies in pathogenesis of asthma and atopic dermatitis, and remarkable therapeutic benefit of monoclonal anti-IgE
• the excessive hygiene hypothesis related to the development of allergy
• the role of Fcy receptors in the pathogenesis of type II and III hypersensitivities
• suppression of graft rejection by synergy between fungal metabolites and other drugs and by induction of antigen-specific tolerance with high-dose
• bone marrow transplantation combined with CO-stimulatory blockade by anti-CD40L and CTLA-4-Ig engineering grafts from recipient cells
• the role of hsp70 and 90 in natural and induced tumor immunity
• peptide priming of dendritic cells to provoke anticancer cytotoxic responses
• the avoidance of graft vs. host disease in allogeneic bone marrow transplantation for leukemias
• inhibition of B-cell lymphomas and tumor angiogenesis by radiolabeled monoclonals
• thymic expression of some organ-specific antigens
• role of autoimmunity to hsp65 in atherosclerosis
• autologous stem cell transplantation after cytotoxic ablative therapy for some cases of SLE, scleroderma and juvenile rheumatoid arthritis

CLICK HERE TO DOWNLOAD

Read More »

Clinical Immunology: Principles and Practice, Third Edition Posted by R Santhosh Kalash on 8/22/2013 05:59:00 pm No comments

Clinical Immunology: Principles and Practice has emerged from this concept of the clinical immunologist as both primary care physician and expert consultant in the management of patients with immunologic diseases. It opens in full appreciation of the critical role of fundamental immunology in this rapidly evolving clinical discipline. Authors of basic science chapters were asked, however, to cast their subjects in a context of clinical relevance. We believe the result is a well-balanced exposition of basic immunology for the clinician.

The initial two sections on basic principles of immunology are followed by two sections that focus in detail on the role of the immune system in defenses against infectious organisms. The approach is two-pronged. It begins first with a systematic survey of immune responses to pathogenic agents followed by a detailed treatment of immunologic deficiency syndromes. Pathogenic mechanisms of both congenital and acquired immune deficiency diseases are discussed, as are the infectious complications that characterize these diseases. Befitting its importance, the subject of HIV infection and AIDS receives particular attention, with separate chapters on the problem of infection in the immuno compromised host, HIV infection in children, anti-retroviral therapy and current progress in the development of HIV vaccines.

The classic allergic diseases are the most common immunologic diseases in the population, ranging from atopic disease to drug allergy to organ-specific allergic disease (e.g., of the lungs, eye and skin). They constitute a foundation for the practice of clinical immunology, particularly for those physicians with a practice orientation defined by formal subspecialty training in allergy and immunology. A major section is consequently devoted to these diseases, with an emphasis on pathophysiology as the basis for rational management.

CLICK HERE TO DOWNLOAD

Read More »

Essential Clinical Immunology Posted by R Santhosh Kalash on 3/31/2013 10:30:00 pm No comments

The ways in which we can better understand cancer, HIV, and other autoimmune diseases through clinical immunology are of great interest to all scientists, from students to post-graduate practitioners. Designed as an introduction to science students (MD, MD–PhD, PhD) as well as to more advanced PhDs and medical practitioners, this book focuses on the importance of immunological concepts in disease states.

Essential Clinical Immunology begins with the basic concepts and then details the immunological aspects of various disease states involving major organs of the body. The book explores how we can better understand disease and its treatment through clinical immunology. Looking forward, each chapter concludes with patterns for future research.

John B. Zabriskie (M.D., Columbia College of Physicians and Surgeons) is Professor Emeritus and former head of the Laboratory of Clinical Microbiology and Immunology at The Rockefeller University, New York, New York. He has written numerous articles on immunology, micro biology, and Neurology.

CLICK HERE TO DOWNLOAD

Read More »

Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders Posted by R Santhosh Kalash on 3/31/2013 03:06:00 am No comments

Immune activation of the central or peripheral nervous system (CNS or PNS) has been shown to play a key role in the pathogenesis of many neurological disorders. Basic concepts in Clinical Neuroimmunology have changed significantly during the last 10 years, and are constantly evolving. New data has driven treatment concepts for a large number of autoimmune diseases, none more so than multiple sclerosis. As this area of research has become increasingly active and productive, the need for a comprehensive up-to-date handbook has become apparent.

Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders has been written with the clinician in mind and targets residents, fellows, internists, nurse practitioners, as well as general neurologists. The aim of this book is to make recent developments in neuroimmunology accessible to the clinician who feels daunted by such advances, and requires a clear explanation of the scientific and clinical issues. The chapters have been written by experts in their fields. The introduction, Part I is written by Patricia K. Coyle and Lloyd Kasper and provide a logical and straightforward overview of neuroimmunology. Part II consists of eight chapters focused on multiple sclerosis. It includes a chapter on Chronic Cerebrospinal Venous Insufficiency (CCSVI), a topic currently getting a great deal of attention in the media. CCSVI is under investigation for its possible association with MS. Another chapter written by Howard Weiner envisions MS 20 years in the future. Part III has seven chapters and focuses on other CNS inflammatory disorders including neuromyelitis optica, ADEM, CNS infections, and immunological aspects of cancer. Part IV includes two chapters that describe autoimmune disorders of the PNS. The final (V) part includes a single chapter that focuses on various systemic diseases with prominent autoimmune CNS and PNS manifestations such as Behcet’s disease, Sarcoidosis, and Systemic Lupus Erythematosis.

CLICK HERE TO DOWNLOAD

Read More »