It is now 30 years since the 1st Edition of Essential Immunology appeared, and it seemed that the time was now appropriate for the task of producing the 10th Edition to be shared. The new co-author, Peter Delves, has been a close colleague of Professor Roitt for many years and is a highly experienced teacher. A wide range of subjects have been extensively revised, restructured or updated, and advanced material is included in the figure legends to avoid disruption of the basic text. These subjects include:
- dendritic cells
- intraepithelial lymphocytes
- NK-T and y6 T-cells
- NK receptors
- receptor editing relating to receptor diversity
- non-classical MHC and the presentation of nonpeptidic
- antigens
- the role of chaperone proteins in antigen processing
- T-cell recognition of peptide-MHC reflecting the
- latest crystallographic studies
- arrays for analysis of gene expression
- tetramer evaluation of antigen-specific T-cells
- experimental genetic manipulation using conditional
- 'knockouts' employing the Lox/Cre
- system and 'knockins' to replace endogenous
- genes
- B- and T-cell signaling pathways and the role of
- adaptor proteins
- cytokine physiology
- chemokines and their receptors
- memory cells
- intimate links of innate and adaptive immunity
- the role of complement in modulating the adaptive immune response
- regulatory T-cells activation-induced cell death
- neuroendocrine influences on the immune system
- critical role of Pax 5 in B-cell differentiation
- molecular basis of thymic development
- signaling through pattern recognition systems
- prions
- viral hijacking of host processes as evasion
- mechanisms
- DNA vaccines
- mucosal adjuvants
- 'shot gun' approach to identification of vaccine
- candidates
- primary immunodeficiency including IL-7 receptor
- mutation, and deficiency of VDJ recombination in
- severe combined immunodeficiency
- CCR5 CO-receptor for HIV infection of cells
- the importance of highly active anti-retroviral drug therapy and of healthy CD8 response dependent on robust CD4 Thl effectors in control of HIV infection
- pivotal role of IgE antibodies in pathogenesis of asthma and atopic dermatitis, and remarkable therapeutic benefit of monoclonal anti-IgE
- the excessive hygiene hypothesis related to the development of allergy
- the role of Fcy receptors in the pathogenesis of type II and III hypersensitivities
- suppression of graft rejection by synergy between fungal metabolites and other drugs and by induction of antigen-specific tolerance with high-dose
- bone marrow transplantation combined with CO-stimulatory blockade by anti-CD40L and CTLA-4-Ig engineering grafts from recipient cells
- the role of hsp70 and 90 in natural and induced tumor immunity
- peptide priming of dendritic cells to provoke anticancer cytotoxic responses
- the avoidance of graft vs. host disease in allogeneic bone marrow transplantation for leukemias
- inhibition of B-cell lymphomas and tumor angiogenesis by radiolabeled monoclonals
- thymic expression of some organ-specific antigens
- role of autoimmunity to hsp65 in atherosclerosis
- autologous stem cell transplantation after cytotoxic ablative therapy for some cases of SLE, scleroderma and juvenile rheumatoid arthritis
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