Thursday, 19 September 2013

Handbook of Reagents for Organic Synthesis: Chiral Reagents for Asymmetric Synthesis

 All of us are aware of the sharp increase in demand for enantiomerically pure reagents and products that has transpired over the past twenty-five years or so. To some extent, the move in this direction has been brought on by the quest by synthetic organic chemists for optically pure natural product targets and for effective asymmetric catalysts. More significantly, this activity has been spurred on throughout the world by governmental oversight agencies whose responsibility it is to guarantee the availability of pure drugs for human consumption. As a consequence, the international medicinal chemistry community continues to upgrade its search for economic ways to develop chiral technology. The need for chiral, nonracemic raw materials, intermediates, and bioactive end products continues to grow at a rapid rate. In the light of these developments, this seemed an appropriate time for assembly into a single volume of a compilation listing many of the optically active reagents and catalysts in use at the present time.

The selection covered in this volume comes from two sources. The first is the Encyclopedia of Reagents for Organic Synthesis (EROS) which was published in 1995. In the intervening time, new entries have been written by many experts in the field for incorporation into the ever-expanding electronic version of the same work (e-EROS). As to be expected, the compilation includes both well recognized and lesser known reagents and ligands. In order to assist the researcher searching for relevant information, this Introduction is followed by a listing of Recent Reviews and Monographs on subjects related to this general theme. Following that, there is a section that illustrates those procedures appearing in volumes 68-78 of Organic Syntheses that feature the detailed preparation of enantiomerically enriched end-products. The overall intent is to assemble in manageable format as much indispensable information dealing with the subject of Chiral Reagents for Asymmetric Synthesis as possible. To this end, the entries are grouped into the following categories: alcohols, aldehydes, amides and lactams, amino compounds, carbohydrate derivatives, diols, esters and lactones, heterocycles, ketones, sulfur compounds, phosphines, and miscellaneous.

In the majority of cases, asymmetric reactions are involved. Enantioselective applications of transition metal catalysts can be found throughout the volume. In the body of the text, no attempt has been made to group the reagents in other than alphabetical order. The benefit derived from scanning its pages is thereby maximized.


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