Human Drug Metabolism, An Introduction, Second
Edition provides an accessible introduction to the subject and
will be particularly invaluable to those who already have some understanding of
the life sciences. Completely revised and updated throughout, the new edition
focuses only on essential chemical detail and includes patient case histories
to illustrate the clinical consequences of changes in drug metabolism and its
impact on patient welfare.
After underlining the relationship between
efficacy, toxicity and drug concentration, the book then considers how
metabolizing systems operate and how they impact upon drug concentration, both
under drug pressure and during inhibition. Factors affecting drug metabolism,
such as genetic polymorphisms, age and diet are discussed and how metabolism
can lead to toxicity is explained. The book concludes with the role of drug
metabolism in the commercial development of therapeutic agents as well as the
pharmacology of some illicit drugs.
0 comments:
Post a Comment