Thursday, 19 September 2013

Organic medicinal and Pharmaceutical chemistry; Eleventh Edition

For almost six decades, Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical chemistry has been a standard in the literature of medicinal chemistry. Generations of students and faculty have depended on this textbook not only for undergraduate courses in medicinal chemistry but also as a supplement for graduate studies. Moreover, students in other health sciences have found certain chapters useful at one time or another. The current editors and authors worked on the eleventh edition with the objective of continuing the tradition of a modem textbook for undergraduate students and also for graduate students who need a general review of medicinal chemistry. Because the chapters include a blend of chemical and pharmacological principles necessary for understanding structure activity relationships and molecular mechanisms of drug action, the book should be useful in supporting courses in medicinal chemistry and in complementing pharmacology courses. It is our goal that the eleventh edition follow in the footsteps of the tenth edition and reflect the dynamic changes occurring in medicinal chemistry. Recognizing that the search for new drugs involves both synthesis and screening of large numbers of compounds, there is a new chapter on combinatorial chemistry that includes a discussion on how the process is automated. The power of mainframe computing now is on the medicinal chemist's desk. A new chapter describes techniques of molecular modeling and computational chemistry. With a significant percentage of the general population purchasing alternative medicines, there is a new chapter on herbal medicines that describes the chemical content of many of these products.

The previous edition had new chapters on drug latentiation and prodrugs, immunizing biological, diagnostic imaging agents, and biotechnology. Expansion of chapters from the tenth edition includes the antiviral chapter that contains the newest drugs that have changed the way HIV is treated. Dramatic progress in the application of molecular biology to the production of pharmaceutical agents has produced such important molecules as modified human insulin, granulocyte colony-stimulating factors, erythropoietins, and interferons. all products of cloned and, sometimes, modified human genes. The chapter on biotechnology describes these exciting applications. Recent advances in understanding the immune system at the molecular level have led to new agents that suppress or modify the immune response, producing new treatments for autoimmune diseases including rheumatoid arthritis, Crohn's disease, and multiple sclerosis. Techniques of genetic engineering now allow the preparation of pure surface antigens as vaccines while totally eliminating the pathogenic organisms from which they are derived.



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