A
panel of highly skilled investigators describe in detail their state-of-the-art
biochemical, cell biological, and molecular biological techniques for studying
the molecular basis of Alzheimer's disease. These readily reproducible,
step-by-step methods focus on work with the amyloid precursor protein and the
amyloidogenic peptide Aß, but also include-with the recent identification of
presenilin proteins-techniques for determining the structure and biological
function of these proteins. In addition, there are chapters covering the tau
protein and its role in Alzheimer's disease, as well as an introductory
discussion of the history of the disease, its genetic basis, and the currently
available and possible future therapeutic agents. Cutting-edge and wide ranging,
Alzheimer's Disease: Methods and Protocols provides ready access to proven,
reproducible methods for elucidating the molecular basis of this most common
senile dementia.
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