Drug Metabolism and Transport: Molecular Methods and Mechanisms Posted by R Santhosh Kalash on 9/19/2013 07:19:00 am No comments

Two key aspects of how the body handles drugs and other chemicals are metabolism and transport. Metabolism is critical because it enables the body to process highly lipophilic molecules for further metabolism and eventual excretion, inactivates biologically active molecules, or detoxifies potentially toxic chemicals. Transport processes are critical because they determine the ability of drugs and other chemicals to gain access to sites of metabolism or to physiological or toxicological targets within tissues. The remarkable advances in molecular and cell biology and the development of novel in vitro model systems to study the various processes involved in metabolism and transport have expanded our knowledge and led to numerous, new therapeutic approaches to treatment of chemically induced toxicity and disease.

Drug Metabolism and Transport: Molecular Methods and Mechanisms, which is part of the Methods in Pharmacology and Toxicology series, presents a collection of chapters on selected aspects of metabolism and transport. The general approach of the chapters is to first present background on the topic to define the state of the science, to summarize key experimental models and methods that are used in the study of the process, and then to evaluate the utility of the various approaches and methods. Along the way, the various authors have endeavoured to provide insight into why each model or approach is advantageous and discuss limitations and cautions in the application of these models or approaches. The goal here is not to provide step-by-step recipes for how to conduct specific assays, although selected procedures are outlined in some detail. Rather, the goal is to present some rationale for why certain models or approaches are used and to describe insight into how they are used to address various issues in drug metabolism and transport.

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