Metabolomics,
the unbiased identification and quantification of all metabolites in a
biological sample, is playing a substantial role in this process. The technology
provides high analytical precision, comprehensiveness, and sample throughput.
However, the physicochemical diversity of metabolites necessitates the
application of different complementary analytical methods. High throughput and
unmatched comprehensiveness for different compound classes makes gas chromatography–mass
spectrometry (GC–MS) technology a superior technique for metabolomics. Most
metabolites can be partitioned into polar and nonpolar fractions, and after
specific derivatization to make each fraction volatile, analyzed using GC–MS. A
major portion of Metabolomics focuses on different GC–MS techniques and
their applications to real-world samples, such as analysis of blood samples.
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