With the completion of gene sequencing projects, scientific interest
is shifting to the investigation of the proteome and metabolome. Broadly
speaking, the metabolome can be considered as the dynamic complement of
metabolites formed by, or found within, a cell type, tissue, body fluid, or
organism; and the study of the metabolome can be viewed as metabonomics or
metabolomics, both of which are applications of metabolite profiling.
Metabolite profiling is not a new concept, and has been successfully used for
the diagnosis of specific diseases for many years. However, with the advent of
high-throughput technology, metabolite profiling is now being used extensively in
the quest for the discovery of markers for a wide range of diseases.
In this volume, we draw together experts in the fields of metabolite
profiling and identification. The main techniques used in metabolite profiling
are mass spectrometry and NMR, and an introduction to these techniques is
covered. There follow chapters on the current application of metabolite
profiling for the diagnosis of disease. Specific classes of metabolites are the
subject of further chapters, and these are followed by chapters on plant
metabolomics and metabolite data mining. Finally, we conclude with a chapter on
global systems biology.
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