The metabolic regulation of a cell system is of critical
importance in systems biology, and a robust model of these mechanisms is essential
in predicting the effects on the metabolism of both the culture environment and
the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject
in relation to culture environment and provides a detailed analysis from gene
level to metabolic level regulation, as well as offering a discussion of the
most recent modelling approaches. The book begins with an introduction to
metabolic mechanisms and to the metabolic regulation of a cell, before moving
on to discussing the action of global regulators in response to a specific
culture environment. The second half of the book examines conventional flux
balance analysis and its applications, 13C-metabolic flux analysis, and the
effect of a specific gene knockout on the metabolism.
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