Sunday, 20 October 2013

Viruses in food and water

Posted by R Santhosh Kalash
on 10/20/2013 01:14:00 pm
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Viruses can be highly infectious and are capable of causing widespread disease outbreaks. The significance of viral pathogens in food and waterborne illness is increasingly being recognised and viruses transferred by these routes are important areas of research. Viruses in food and water reviews the risks, surveillance and control of food and waterborne viral disease.  Part one provides an introduction to food and environmental virology. Part two goes on to explore methods of detection, surveillance and risk assessment of...

Toxicity of Heavy Metals to Legumes and Bioremediation

Posted by R Santhosh Kalash
on 10/20/2013 01:07:00 pm
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Toxicity of heavy metals to legumes and bioremediation presents numerous aspects of metal toxicity to legumes and suggests quite a few bioremediation strategies that could be useful in restoring contaminated environments vis-a-vis legume production in metal-stressed soils. The mobility and availability of toxic metals, nutritive value of some metals, and the strategies to assess the human health risk by heavy metals are reviewed and highlighted. Heavy metal toxicity to symbiotic nitrogen fixing microorganism and host legumes is dealt separately....

Toxic Plants of North America, 2nd Edition

Posted by R Santhosh Kalash
on 10/20/2013 01:06:00 pm
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Toxic Plants of North America, Second Edition is an up-to-date, comprehensive reference for both wild and cultivated toxic plants on the North American continent. In addition to compiling and presenting information about the toxicology and classification of these plants published in the years since the appearance of the first edition, this edition significantly expands coverage of human and wildlife—both free-roaming and captive—intoxications and the roles of secondary compounds and fungal endophytes in plant intoxications. More than...

Synthetic Biology

Posted by R Santhosh Kalash
on 10/20/2013 12:56:00 pm
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Synthetic Biology utilizes the design and construction principles of engineering to develop new biological components and systems or embed novel functions into existing ones, and standardize their behavior. This systematic approach to improving and increasing the programmability and robustness of biological components is expected to lead to the facile assembly of artificial biological components and integrated systems. While there has been considerable success in the field, it is still far from its full potential, with major challenges including standardization...

Stem Cell Biology in Normal Life and Diseases

Posted by R Santhosh Kalash
on 10/20/2013 12:54:00 pm
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Stem cells have a prominent role in biology of normal life and also in pathogenesis of diseases. Life starts with generation of an embryo (the most primitive form of a stem cell) and goes through all of the embryonic and fetal stages of life. It forms all of the tissue and organs of a living organism and then has a role in maintenance of normal cellular composition of body. And finally these cells maintain body in a steady state of cell loss and substitution of normal lost/died cells by new normal cells. Nearly in every organ of body we have...

Sirtuins

Posted by R Santhosh Kalash
on 10/20/2013 12:49:00 pm
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The sirtuins are a family of genes encoding NAD(+)-dependent protein deacylases conserved in several organisms including yeast, worms, flies, and mammals. This family of genes has been shown to play crucial roles in the molecular pathways that regulate cell survival, metabolism, and the diseases of aging. Because of the diverse roles sirtuins play, research in the area of sirtuins has expanded into multiple disciplines at an accelerated pace, identifying new and unexpected roles for this family of genes. A diverse array of model organisms and scientific...

Sex Determination in Fish

Posted by R Santhosh Kalash
on 10/20/2013 12:38:00 pm
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Sex Determination in Fish is the first to report that research in allogenics/xenogenics has conclusively shown that fishes have retained bisexual potency even after sexual maturity and spermiation. The XY genotype found in the unexpected female phenotypes sired by supermales (Y1Y2) and androgenic males (Y2Y2) points out the need to employ sex specific molecular markers to identify the true genotype of a juvenile, which matures either as a male or female, depending upon the sex of its pair (female or male) and thereby critically assessing the...

Proteomics for Biomarker Discovery

Posted by R Santhosh Kalash
on 10/20/2013 12:36:00 pm
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With the advent of proteomics came the development of technologies, primarily mass spectrometry, which allowed high-throughput identification of proteins in complex mixtures. While the mass spectrometer resides at the heart of proteomics, its ability to characterize biological samples is only as good as the sample preparation and data analysis tools used in any study. Not only has proteomics increased our capacity to identify proteins, it has enabled other characteristics of proteomes to be measured. Of utmost interest has been the development...

Principles of Plant Genetics and Breeding; Second Edition

Posted by R Santhosh Kalash
on 10/20/2013 12:34:00 pm
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To respond to the increasing need to feed the world's population as well as an ever greater demand for a balanced and healthy diet there is a continuing need to produce improved new cultivars or varieties of plants, particularly crop plants. The strategies used to produce these are increasingly based on our knowledge of relevant science, particularly genetics, but involves a multidisciplinary understanding that optimizes the approaches taken. Principles of Plant Genetics and Breeding, 2nd Edition introduces both classical and molecular...

Pluripotent Stem Cells

Posted by R Santhosh Kalash
on 10/20/2013 12:32:00 pm
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Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have...

Plant Breeding from Laboratories to Fields

Posted by R Santhosh Kalash
on 10/20/2013 12:29:00 pm
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Breeding of crop plants to make them more adapted to human agricultural systems has been on-going during domestication the last 10,000 years. However, only recently with the invention of the Mendelian principles of genetics and the subsequent development of quantitative genetics during the twentieth century has such genetic crop improvement become based on a general theory. During the last 50 years plant breeding has entered a molecular era based on molecular tools to analyse DNA, RNA and proteins and associate such molecular results with...

Plant Mineral Nutrients

Posted by R Santhosh Kalash
on 10/20/2013 12:25:00 pm
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Plants require a range of essential macro and micronutrients for their growth and development. For terrestrial plants, all mineral nutrients derive from the soil. Although research into the roles and functions of such minerals stretches back more than 150 years, there are still many unresolved questions, even where the definition of “essential mineral” is concerned. The study of plant mineral nutrition has both academic and applied aspects to it.  The simple fact that the human diet is, directly or indirectly, plant based has obvious and...

Pheromone Signaling

Posted by R Santhosh Kalash
on 10/20/2013 12:23:00 pm
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Providing experimental methods and protocols for performing pheromone research in a variety of organisms ranging from invertebrates to vertebrates, Pheromone Signaling: Methods and Protocols covers a wide spectrum of experimental approaches necessary for handling pheromone molecules, measuring receptor response and neural activation, and analyzing behavioral output. A great deal of progress has been made in understanding the molecular mechanisms underlying pheromone action, largely due to the discovery of receptor genes, the advancement...

Peptide Modifications to Increase Metabolic Stability and Activity

Posted by R Santhosh Kalash
on 10/20/2013 12:22:00 pm
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Historically, natural products have served as important sources of pharmacologically active compounds or lead structures for the development of new drugs. Among natural products, peptides are particularly interesting because of the key roles they play in biological processes. Peptides’ potential for high efficacy and their minimal side effects combined with advances in recombinant DNA technology, solid-phase synthetic chemistry, purification technology, and new strategies for peptide drug delivery made them widely considered as lead compounds...

Oxidative Stress and Nanotechnology

Posted by R Santhosh Kalash
on 10/20/2013 12:20:00 pm
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Over the past decade, nanotechnology has been a buzzword that the scientific community has embraced with great compassion. The emergence of nanotechnology has had a profound effect on almost every aspect of the twenty-first century’s daily life. It has had a revolutionary impact from stain-resistant clothing and cosmetics to environmental issues, including energy and medicine and even aerospace engineering. This volume, comprised of nine Reviews, nine new Protocols, and one Future Directions chapter, is an endeavor to present various aspects...

Neural Stem cells – New perspectives

Posted by R Santhosh Kalash
on 10/20/2013 12:15:00 pm
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During the last two decades stem cell biology has changed the field of basic research in life science as well as our perspective of its possible outcomes in medicine. At the beginning of the nineties, the discovery of neural stem cells in the mammalian central nervous system (CNS) made the generation of new neurons a real biological process occurring in the adult brain. Since then, a vast community of neuroscientists started to think in terms of regenerative medicine as a possible solution for incurable CNS diseases, such as traumatic injuries,...

Molecular Imaging: Fundamentals and Applications

Posted by R Santhosh Kalash
on 10/20/2013 12:11:00 pm
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Molecular Imaging: Fundamentals and Applications" is a comprehensive monograph which describes not only the theory of the underlying algorithms and key technologies but also introduces a prototype system and its applications, bringing together theory, technology and applications. By explaining the basic concepts and principles of molecular imaging, imaging techniques, as well as research and applications in detail, the book provides both detailed theoretical background information and technical methods for researchers working in medical imaging and...

MicroRNAs from basic science to disease biology

Posted by R Santhosh Kalash
on 10/20/2013 12:09:00 pm
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MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will...

MicroRNA Protocols

Posted by R Santhosh Kalash
on 10/20/2013 12:07:00 pm
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miRNAs, small single-stranded hairpin RNAs capable of interfering with intracellular mRNAs that contain partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. This characteristic is different from siRNA because a rigid complete complementarity is required for siRNA-induced RNAi gene silencing. miRNA was originally discovered in Caenorhabditis elegans as native RNA fragments that modulate a wide range of genetic regulatory pathways during animal development. Recently, findings of intron-derived...

Measurement, Monitoring, Modelling and Control of Bioprocesses

Posted by R Santhosh Kalash
on 10/20/2013 12:04:00 pm
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In 1988, the European Federation of Biotechnology EFB founded a new Working Party with the target to deal with measurement and control of bioprocesses. This was an ambitious move. Now, some two decades later a myriad of new issues within this broad scope have arisen: bioprocess performance monitoring, fault detection, experimental design, modelling of bioreactors and bioprocesses, fighting ‘‘data drowning’’, detection and monitoring of impurities, faster product innovation together with the reconfiguration control and integrated design. There...

Mass Spectrometry of Glycoproteins

Posted by R Santhosh Kalash
on 10/20/2013 11:47:00 am
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Glycosylation is the most abundant post-translational modification of proteins. Estimates vary widely, but a common assessment is that upwards of 50% of eukaryotic proteins are modified by some type of glycan. Indeed, the difficulties associated with accurately assessing the glycosylation status of intra- and extracellular proteins are the primary motivations for this volume. Over the past 30 years, insight into the biological roles of glycan modifications has grown dramatically, yet this field has often struggled due to the inadequacies of accessible...

Marine Proteins and Peptides

Posted by R Santhosh Kalash
on 10/20/2013 11:35:00 am
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Food proteins and bioactive peptides play a vital role in the growth and development of the body’s structural integrity and regulation, as well as having a variety of other functional properties. Land animal-derived food proteins such as collagen and gelatine carry risks of contamination (such as BSE). Marine-derived proteins, which can provide equivalents to collagen and gelatin without the associated risks, are becoming more popular among consumers because of their numerous health beneficial effects. Most marine-derived bioactive peptides...

Lipoproteins and Cardiovascular Disease

Posted by R Santhosh Kalash
on 10/20/2013 11:27:00 am
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Methods in Molecular Biology : Lipoproteins and Cardiovascular Disease: Methods and Protocols is a compendium of advanced and classical molecular biology methods targeted towards lipoprotein, atherosclerosis, and vascular biology research. Lipoprotein, atherosclerosis, and vascular biology studies present unique challenges to the molecular biologist. The lipid-rich and otherwise challenging nature of many key tissues complicate the isolation of high-quality RNA for gene expression analysis, for example, and the unique nature of lipoproteins...

Lactic Acid Bacteria: Microbiological and Functional Aspects; Fourth Edition

Posted by R Santhosh Kalash
on 10/20/2013 11:25:00 am
1 comment
The previous editions of this book have never looked very much like their predecessors, and this fourth edition is no exception. Due to the accumulation of new findings during the seven years that has passed since the previous update, practically all chapters are either completely rewritten or are totally new. We (the editors) and the contributors have strived to reach a proper balance between the well-established “eternal truths” and the novel and even controversial findings. While keeping the format of individual chapters as reviews, a certain compromise...

Janeway’s Immunobiology

Posted by R Santhosh Kalash
on 10/20/2013 11:18:00 am
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Janeway's Immunobiology is intended for undergraduate and graduate courses in immunology, as well as for medical students. The book can be used as an introduction to immunology but its scope is sufficiently comprehensive and deep to be useful for more advanced students and working immunologists. Immunobiology presents immunology from the consistent viewpoint of the host's interaction with an environment full of microbes and pathogens, and illustrates that the loss of any component of this system increases host susceptibility to some particular infection....

Immunocytochemistry of Plant Cells

Posted by R Santhosh Kalash
on 10/20/2013 11:13:00 am
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Immunocytochemistry of plant cells has come a long way from the first review on this subject by Bruce Knox in the early 1980s. In that early review, our only tools were fluorescein-labeled antibodies for light microscopy and ferritin-labeled antibodies for electron microscopic observation. Frankly, in many of these early localizations the resolution of the tissue or the specificity of the labeling left much to be desired. Immunocytochemistry of Plant Cells is the first book exclusively dedicated to this topic. The first and largest portion...

Human Monoclonal Antibodies

Posted by R Santhosh Kalash
on 10/20/2013 11:11:00 am
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The introduction of monoclonal antibodies revolutionized immunology. The development of human monoclonal antibodies was inspired primarily by the enormous clinical benefits promised by these reagents which can be used as anti-inflammatory reagents, anti-tumor reagents and reagents for passive immunization in a variety of pathologies. Human Monoclonal Antibodies: Methods and Protocols presents technical protocols of cellular and molecular methods for the production, purification and application of human monoclonal antibodies, as well...
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